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Letrozole is used alone or with other treatments to treat early breast cancer in postmenopausal women. It belongs to a class of drugs called aromatase inhibitors, which decrease the amount of estrogen in the body.
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✅ Description:
Lerozol 2.5 mfg Tablet contains Letrozole, a hormonal chemotherapeutic agent used for treating breast cancer in postmenopausal women. It can be used as initial therapy or after treatment with other medications like tamoxifen. This medication is also effective for advanced breast cancer that has spread to other parts of the body.
Breast cancer is characterized by the uncontrolled growth and division of cells in the breast, often triggered by hormonal imbalances or lifestyle factors. Symptoms may include breast pain, changes in breast color, nipple discharge, and the development of lumps.
Before taking Lerozol, inform your doctor about any kidney or liver issues you may have. Also, disclose any history of bone problems such as osteoporosis or joint pain.
Lerozol is only suitable for menopausal women and is not recommended for use during pregnancy due to potential harm to the fetus.
Safety Advices
Alcohol
UNSAFE
Consuming alcohol with Lerozol does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Lerozol is highly unsafe to use during pregnancy. Significant harmful effects on the developing baby have been observed in studies on pregnant women and animals. Seek your doctor's advice.
Breastfeeding
CONSULT YOUR DOCTOR
Lerozol is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. Avoid breastfeeding while using Lerozol.
Driving
CAUTION
Lerozol may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Lerozol is safe to use in patients with kidney disease. No dose adjustment of Lerozol is recommended. However, caution is advised, especially in patients with end-stage kidney disease.
Liver
CAUTION
Lerozol should be used with caution in patients with liver disease. Dose adjustment may be needed. Consult your doctor before using Lerozol if you have liver issues.
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✔️ Uses of Lerozol 2.5
Breast cancer, infertility due to anovulation.
✔️ Side Effects of Lerozol 2.5
Common:
Hot flushes, hypercholesterolemia, fatigue, chest pain, arthralgia, skin rash, headache, dizziness, gastrointestinal disorders, muscle pain, osteoporosis, edema, depression, weight increase, hair loss, increased sweating, hypertension, abdominal pain, dry skin, vaginal bleeding, palpitations, joint stiffness,
Rare:
Anxiety, irritability, memory problems, insomnia, carpal tunnel syndrome, eye irritation, itching, vaginal discharge/dryness, weight decrease, urinary tract infection, cough, elevated enzyme levels, and jaundice.
✔️ How does Lerozol 2.5 work?
Lerozol decreases the amount of estrogen produced in the body, which can slow down or stop the growth of certain types of breast cancers. It also increases the release of certain hormones to stimulate the release of eggs from the ovaries in infertility cases.
✔️ Quick Suggestions:
- It may cause increased sweating and hot flashes. Try to keep cool by wearing light and airy clothes.
- Your doctor may monitor your cholesterol level and bone mineral density (BMD) regularly as Lerozol can alter their levels.
- Do not take Letrozole if you are pregnant or breastfeeding
- Letrozole should be used with caution in elderly patients (aged 65 years or older)
✔️ Indication of Lerozol 2.5
- Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
- Adjuvant treatment of postmenopausal women with early breast cancer who have received 5 years of adjuvant tamoxifen therapy.
- First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer.
- Treatment of advanced breast cancer in women with postmenopausal status.
- Pre-operative therapy in postmenopausal women with localized hormone receptor-positive breast cancer.
✔️ Pharmacology
Letrozole competitively binds to the heme group of aromatase, leading to inhibition of the enzyme and a significant reduction in plasma estrogen levels.
✔️ Dosage & Administration of Lerozol 2.5
For advanced or locally advanced breast cancer, and adjuvant therapy for postmenopausal women with hormone receptor-positive early breast cancer: 2.5 mg once daily. Dose adjustments may be necessary for patients with hepatic impairment.
✔️ Interaction
Plasma levels of Letrozole may be reduced by tamoxifen.
✔️ Contraindications
✔️ Pregnancy & Lactation
Not recommended during pregnancy due to teratogenicity.
Avoid in nursing women due to potential risk to infants.
✔️ Precautions & Warnings
Severe renal impairment, severe hepatic impairment, osteoporosis. Caution when driving or operating machinery. Consult your doctor before use if you have liver or kidney issues.
✔️ Storage Conditions
Store below 30°C, away from light & moisture. Keep out of reach of children.
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